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Tirzepatide versus semaglutide dosing Semaglutide follows a four-step titration schedule: 0.25 mg for 4 weeks, 0.5 mg for 4 weeks, 1 mg for 4 weeks, and then 1.7 mg or 2.4 mg as the maintenance dose

Long-term data on semaglutide now extends beyond 5 years for diabetes indications and approximately 3 years for weight management

The central compartment volume is approximately 2.47 liters per 70 kilograms of body weight

Participants lost up to 22.5% of their body weight over 72 weeks with the highest dose (15 mg)

Tirzepatide did not show any effect, demonstrating that this dual GLP-1/GIP receptor agonist did not get into the brain at doses required for target engagement