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The theory of the origin of sleep which has gained the widest credence is the one that attributes it to anemia of the brain The idea behind this supposition has been that, as the day draws to an end, the circulatory mechanism becomes fatigued, the vasomotor center exhausted, the tone of the blood vessels deficient, and the energy of the heart diminished, and thus is the circulation to the cerebral arteries lessened. NATURE, May 5th, 1898

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However, please contact your doctor if the negative effects continue

That system can break down if you: Take acid blockers (PPIs like omeprazole) or antacids regularly Have low stomach acid from age or chronic stress Have had GI surgery (gastric bypass, bowel resection) Live with conditions like celiac, Crohns disease, or IBS Have autoimmune pernicious anemia Even with high-dose tablets (e.g., 1000 mcg), only a small fraction may reach your bloodstream