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In rare instances, repeated injections of certain lipotropic components have led to inflammation or small nodules forming under the skin at the injection site

For example, if you have a gastrointestinal disorder that affects nutrient absorption, or if you follow a vegan or vegetarian diet, you may be at higher risk of developing a deficiency and may require supplementation

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Also in Japan, kidney dialysis patients with polyneuropathy received 5,000g methyl B12 shots, three times a week for six months

What the science actually says Here is where the marketing and the evidence part ways: Metabolism