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However, bioavailability data for intranasal delivery remains limited compared to the well-characterized subcutaneous route

Exp Cell Res (2017) 357(2):15562

Upon entry into neutrophils via the SLC2A9 urate transporter protein, sUA regulates the intracellular pH, modifies cytoskeletal dynamics to reduce cellular size, and manages 2 integrin activity as well as its internalization/recycling, leading to an overall decrease in neutrophil functions such as migration

Institute of Medicine (US) Committee on Data Standards for Patient Safety, Aspden P, Corrigan JM, Wolcott J, Erickson SM, eds

10.1097/JCMA.0000000000000145 124 YooB