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In a chronic model, mice were treated with Icariin 25 mg per kg administered intraperitoneally to 10 days before the initial dose of CYP that is 75 mg per kg given through an intraperitoneal route every 3 days for about 10 days to decrease the edema and hemorrhage of bladder, vascular permeability, and mast cells infiltration as well as fibrosis of the lesion tissue