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ROCK2 signaling is critical in regulating vascular tone, cytoskeletal dynamics, intercellular adhesion, and endothelial barrier function [36]

We believe that one of the important mechanisms underlying this effect is likely reduction of inflammation in the fatty tissue around the heart, which we know is an important driver of arrhythmias and other unwanted cardiac outcomes. Bilchick plans to continue investigating these inflammatory mechanisms in collaboration with UVA immunology researcher Coleen McNamara, UVA MRI physicist Frederick Epstein (who developed an MRI method to characterize fatty tissue surrounding the heart), and UVA Director of Cardiac Imaging Amit Patel

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10.3389/fpls.2016.01109 110 McGoldrickS.O'SullivanS