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Blood levels rise across the first several weekly doses and settle near steady state after about four weeks. That is why the four-week hold matters: the full effect of a dose change is not visible in the first few days

Sci Adv 10:eads5466

Blood levels quickly rise to 560,000,000pmol/L, and if necessary, treatment is repeated within hours for a total of 10,000,000mcg of B12

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Because alcohol interferes with how the body absorbs, stores, and metabolizes these nutrients, replenishing them through a nutrient-rich diet or a B-complex supplement (with a clinician's input) is one of the steps the post recommends for people cutting back or quitting