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Clinical experience with crizotinib in patients with advanced ALK-rearranged non-small-cell lung cancer and brain metastases

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Dehydration represents an important factor, as GLP-1 medications can cause nausea, vomiting, and diarrhea, particularly during dose escalation, leading to volume depletion

The addition of the acetyl group also endows acetyl L-carnitine (ALC) with a greater solubility in water, which enables it not only to diffuse easily across the inner wall of the mitochondria and into the cell cytosol, but also cross cell membranes in general more easily

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