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GLP-1 medications can help you lose weight, but maintaining results is a shared effort between medication, biology, and daily habits

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Chemogenetic activation of hypothalamic GIPR+ neurons reduces food intake in mice [90], and GIP reduces food intake when given peripherally (in mice) or via intracerebroventricular injection [91, 92]

10.1002/gps.4196 2

To compensate for reduced MTHFR activity, individuals with MTHFR variations may need to consume more folate and/or take supplements of 5-MTHF