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The first multicentre, prospective, double-blind, placebo-controlled study to assess the usefulness of acetyl-l-carnitine in peripheral neuropathy was conducted by De Grandis et al

Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself

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