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Statements Author contributions UF and GZ contributed to the conception and design of the study and wrote sections of the manuscript

Notably, mutations in TP53 not only change its conformation but also cause p53 aggregation, and p53 aggregation in cells is more consequential than conformational changes

Phosphagenics pain patches use its TPM (targeted penetration matrix) drug delivery technology, which allows molecules to be delivered either into the skin or through the skin into the bloodstream

Healing Support: Enhanced blood flow supports faster recovery and reduces pain

Treatment response depends on deficiency severity, route of administration, underlying cause, patient age, concurrent medical conditions, and medication interactions