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The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract

His story was familiar: young guy buries himself in his career, winds up in terrible shape, cashes out, and starts looking for a health intervention

perhaps those whose mothers have excessively high levels of vitamin B) might be identified, and use of the drug in these individuals could be avoided while others could benefit from use of the drug

This is a scientific certainty and therefore a futile strategy

10.1126/science.248.4963.1637 Science 166 SonderbyI