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10.1161/STROKEAHA.116.015609 Summary Keywords CHAC1, CHAC2, glutathione, ferroptosis, cancer, BOTCH, endoplasmic reticulum stress Citation Schrder E, Jalilvand TV, Kahl J, Kaiser CS and Liebau E (2025) The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications
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Specific contraindications according to FDA prescribing information include personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
The discussion also examines FDA-approved indications, dosing schedules, and known adverse-event profiles to clarify safety considerations