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Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

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Phentermine is not reported on the Semaglutide label as a potential drug interaction but its label has the caution mentioned for combining Phentermine with Semaglutide present in Ozempic and Rybelsus

In addition, among Medicare beneficiaries with type 2 diabetes, the use of GLP-1s has been significantly associated with a decreased risk of PD