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A proof-of-concept experiment in transgenic mice (the insulin-resistant db/db mouse model which harbors a mutated leptin receptor) showed that overexpression of OGA, which reduces the level of O -GlcNAcylation, significantly improves whole-body glucose tolerance and insulin sensitivity

Cagrilintide as a monotherapy has demonstrated an ability to induce significant body-weight reductions compared with placebo, with synergistic effects when added to semaglutide [52, 53]

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Results: The positive control group (G2) experienced significant reductions in body weight (BW), BW gain, serum glucose, lipase, amylase, total antioxidant capacity, several hematological indices, and total proteins, along with alterations in various antioxidant enzymes

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