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Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Typically, gastrointestinal (GI) side effects of GLP-1s, such as nausea and vomiting, are dose-dependent, mild-to-moderate in severity and occur mostly during initiation of therapy and up-titration

MT-II acts as a non-selective agonist at the melanocortin receptors (MC1R, MC3R, MC4R, and MC5R)

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