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In both in vitro and in vivo models, PQ induces ferroptosis and iron overload by significantly increasing iron accumulation in the cytoplasm and mitochondria via the NCOA4-mediated ferritinophagy pathway

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Users do not report the hand numbness, tingling, or grip weakness associated with carpal tunnel

When selenium levels fall below optimal ranges, the cascade of effects extends far beyond hair loss, potentially impacting fertility, cognitive function, and even increasing the risk of conditions such as Alzheimers disease

Tissue-level data paint the same picture