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SAM is synthesized from the essential amino acid, methionine

This study underscores the symptomatic and therapeutic similarities between ME/CFS and long COVID and highlights the commonalities and nuanced complexities of infection-associated chronic diseases and related conditions

It is thought that the phenomenon may reflect activation of lymphocytes by the lymphokine and lymphokine and cell-mediated attack on thyroid tissue(33)

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[1] The disorder results from an antibody, called thyroid-stimulating immunoglobulin (TSI), that has a similar effect to thyroid-stimulating hormone (TSH)