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2 Ferroptosis: a unique form of regulated cell death 2.1 Definition, characteristics, and development of ferroptosis The concept of ferroptosis can be traced back to the discovery of erastin, a new agent identified in 2003 as an ferroptosis inducer

These alterations in protein expression could potentially be ascribed to the intricate regulatory network of the NRF2/KEAP1 complex: Under homeostatic conditions, NRF2 is continuously ubiquitinated and targeted for 26S proteasomal degradation by its negative regulator KEAP1

Ferrodifferentiation regulates neurodevelopment via ROS generation

This research points to a role for Akkermansia in gut-barrier and metabolic health generally

By contrast, our data reveal that physiological hypoxia fundamentally reprograms this canonical circuit: despite intact EBV oncogenic signaling, FAS is curtailed, exogenous unsaturated fatty acids become essential, and protective TG storage is engaged