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Lancet Diabetes Endocrinol 2019;7:51527.PubMed 26
Tirzepatide, a dual GIP/GLP-1 receptor agonist, has a slightly different receptor activity profile and may be tolerated differently, though gastrointestinal side effects remain common
Boosting NAD + via the de novo pathway through Trp supplementation is not as popular, as quinolinic acid generated from Trp conversion is neurotoxic, and kynurenines have immunomodulatory roles 58
However, during its research and development, it was found to have a surprising side effect: enhancing sexual arousal
investigational and not approved for any such use
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