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The single largest contributor to DXA-measured lean-mass loss during GLP-1 treatment is probably the liver, which counts as lean tissue on DXA alongside muscle

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Key Takeaways Semaglutide quickly reduces appetite, which changes nutrition even if patients do not expect it

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Therefore, if GLP-1 RA treatment specifically increases the risk of pancreatitis in this vulnerable population, such an effect would likely remain undetected in randomized trials