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Proven Track Record# Recommendation : Semaglutide Reason : Approved since 2017 with 7+ years post-marketing data, 25,000+ trial participants, and multiple formulations

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Collectively, these data indicate that pharmacologic administration of GLP-1 (9-36amide) may have a functional role to improve recovery from I/R injury via GLP-1R-independent mechanisms, whereas GLP-1 (7-36amide) but not GLP-1 (9-36amide) affects cardiac contractility via GLP-1R signaling [201]

PubMed Central, de Luis, Daniel Antonio, Gonzalo Diaz Soto, et al

Efficacy and safety of tirzepatide in type 2 diabetes: A comprehensive review