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Graphical Abstract Access this article Similar content being viewed by others Data Availability The dataset analysed in the current study is not publicly available as this is not approved by the participants within the framework of the general informed consent

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The SURMOUNT-5 trial showed that maximum-dose tirzepatide produces about 47% more weight loss than maximum-dose semaglutide, so they are clearly not equivalent at their respective maximums

Tirzepatides unique mechanism involves stimulating GLP-1 and GIP receptors, effectively combining the actions of two distinct hormones which can lead to improved blood sugar levels and enhanced weight loss compared to semaglutide