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AF17-6 Ub: Ubiquitin S3: 15-oxospiramilactone SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 SDH: Succinate dehydrogenase SIRT1: Sirtuin 1 SMA: Spinal muscular atrophy SMAC: Second mitochondrial activator of caspases SN: Substantia nigra SNpc: SN pars compacta SOD2: Superoxide dismutase 2 S-OPA1: Short OPA1 SS: Szeto-Schiller T2DM: Type 2 diabetes mellitus TALE: Transcription-activator-like effector TALEDs: Transcription-activator-like effector -linked deaminases TAMs: Tumor-associated macrophages TBK1: TANK-binding kinase 1 TCA: Tricarboxylic acid TIM: The inner membrane translocase complex TLR: Toll-like receptor TME: Tumor microenvironment TMPRSS2: Transmembrane serine protease 2 TNF-: Tumor necrosis factor TNTs: Tunneling nanotubes TPP: Triphenylphosphonium TRAK: Trafficking kinesin-binding protein UCHL-1: Ubiquitin carboxyl-terminal hydrolase ligase-1 UCP2: Uncoupling protein 2 ULK1: Unc-51-like autophagy activating kinase 1 UPR: Unfolded protein response USP19: Ubiquitin-specific peptidase 19 VDAC: Voltage-dependent anion channels VPS13 C: Vacuolar protein sorting 13C VSMCs: Vascular smooth muscle cells XIAP: X-linked inhibitor of apoptosis References Landoni JC, Kleele T, Winter J, Stepp W, Manley S