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NIH/PMC review publications on cytoprotection, the NO system and wound healing

In a real-world observational study of GLP-1 receptor agonist users, nutritional deficiencies were diagnosed in 12.7% by 6 months and 22.4% by 12 months , with vitamin D deficiency most common

A recent multicenter international phase II RCT (GOLDEN-505) in noncirrhotic biopsy-proven NASH patients showed an insignificant difference in NASH resolution without fibrosis progression between the elafibranor and placebo groups at 52 weeks of treatment

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Overall, the most frequently reported reasons for premature discontinuation from the study were similar across both pooled treatment groups and included withdrawal by participant (pooled tirzepatide group: 117 (2.3%) participants as compared to the pooled comparator group: 70 (2.8%) participants) and lost to follow-up (pooled tirzepatide group: 73 (1.5%) participants as compared to the pooled comparator group: 47 (2.0%) participants)