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Activation of MC1 receptors can darken skin (hence why its precursor was a tanning agent), and indeed using bremelanotide frequently can cause increased melanin production and hyperpigmentation (darkening of the skin) in some users

Diabetologia 57 (4), 781784

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This week were on spring break in Costa Rica, where I had something called a sculptural facial which is less a facial and more a deep face, neck, and shoulder massage with lymphatic drainage

These mechanisms are studied exclusively in experimental environments to better understand peptide-mediated signaling behavior at the molecular level and its influence on coordinated cellular responses associated with aging research