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Similar findings have been demonstrated by agouti-related peptide through melanocortin-3 and -4 receptors (MCR3, MCR4) or by endogenous opioid peptides at - and -opioid receptors 86,87,88

While the study was too small and of too short duration to make any conclusions about the role of NAC in these conditions, what is notable is that through intravenous administration of NAC, brain levels could be altered