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2000) and its inhibition (for instance by S-nitrosylation) may result in anti-inflammatory effects (Morris et al

Furthermore, the T helper 1/T helper 2 (Th1/Th2) immune axis typically shifts toward a pro-inflammatory Th1 bias: peripheral blood from depressed patients often shows elevated levels of Th1-type cytokines such as IFN- and interleukin-2 (IL-2), with a concomitant decrease in Th2 factors