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Therefore, ghrelin and the GHSR-1a receptor, have been extensively investigated as potential therapeutic targets to tackle metabolic, eating- and appetite-related disorders by virtue of the unique position which the ghrelinergic system occupies at the interface of homeostatic and hedonic feeding

AMP-activated protein kinase (AMPK) is a heterotrimeric complex recognized as a critical sensor of cellular energy status, with broad relevance across metabolic research disciplines

According to Mahmoud et al

(PubMed) Bone RC, Balk RA, Cerra FB, et al