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GLP-1 receptors in the hypothalamus and brainstem mediate appetite suppression and increased satiety , contributing to reduced food intake and weight loss

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& Ungprasert, P

In this context, research strategies aimed at the selective inhibition of FOXO proteins including the use of peptide analogs such as FOXO4-DRI represent a promising approach for investigating the modulation of metabolic pathways, with potential relevance to diabetes-related complications

Due to the high heterogeneity, we performed a leave-one-out (LOO) analysis, which revealed no meaningful reduction in heterogeneity in any scenario (Fig