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Similar efficacy and safety results were reported in an exploratory population of patients 1321 years of age with type 2 or type 3 SMA who received apitegromab 20 mg/kg (LSM difference compared to placebo in change in HFMSE, 1.8 points)

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The preparation method according to any one of claims 1 to 5, wherein in the fragmental synthesis of the Lys 26 side chain, the recrystallizing is performed with one or a mixture of two or more of Et 2 O, CH 2 Cl 2 , CHCl 3 , MeOH, CH 3 CN, THF, EtOAc, EtOH, Toluene, Hexane, or Acetone