Likewise, fully maintained spatial learning and memory of the rats in the Morris water maze test was ascribed to hippocampal synaptic plasticity and NMDA receptor function [237] involving the entorhinal and perirhinal cortices, the prefrontal cortex, the cingulate cortex, the neostriatum, and perhaps even the cerebellum in a more limited way [237]
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Then, the response of the system to growth factors like vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF) was evaluated, to both assess the pro-angiogenic effect and the absence of undesired off-target effect
doi:10.4103/0253-7613.174428 Thies F, Mills LM, Moir S, Masson LF
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