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Future preclinical studies should incorporate both sexes and model chronic, relapsing drug use to enhance ecological validity

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Patients often face challenges such as emotional eating, which can be a psychological barrier to maintaining weight loss after discontinuing medication

Future clinical trials should refine the investigation of the direct analgesic properties of GLP-1RAs in osteoarthritis, differentiating these from the benefits linked to weight reduction, to better evaluate their clinical utility in managing osteoarthritis-related pain

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