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Unfortunately, the mechanisms by which these effects occur are still unclear, and significantly more resources and studies are needed to define these effects so that they can be specifically targeted and ameliorated in PLWH, particularly those vulnerable populations of PLWH with SUD or who are using dopaminergic therapeutics

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A reliable K D value for human serum albumin was determined and it was demonstrated that metallated ceruloplasmin is resistant for copper release by chelators used, whereas alpha-2 macroglobulin does not bind Cu(II) ions