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110,111 Whilst duration of NAC supplementation appears to be important, another potential cause for some of the heterogeneity observed in clinical trials may be the length of time patients have been suffering from schizophrenia, with those with a history of schizophrenia for 20 years or more responding best to NAC

This is the problem of accurate measurement of the levels of different glutathione forms, particularly reduced (GSH) and oxidized (GSSG) forms, their ratio (an index of redox potential), and mixed thioethers need further experimental development

40,41 Although the first major randomized clinical trial for this approach REDUCE LAP-HF II demonstrated no difference in cardiovascular outcomes between the group treated with IASD vs

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