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The matricellular protein Wisp1 is a circulating factor that has been recognized as an adipokine

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XQ-1H alleviates BBB leakage in ischemic stroke model mice increasing the expression of claudin-5, occludin, ZO-1, and B-catenin [122]

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This heterogenicity of tumors and the resulting convoluted nature of biomarkers makes personalized cancer treatments challenging, especially considering that combinations of multiple markers correlate with different outcomes compared to single markers