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For NAC intervention experiments, rats were co-treated with N-acetylcysteine (NAC, Sigma Aldrich

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This classification is based on the oxidation state and substitution pattern of the central heterocyclic C-ring ( 3.2 Natural dietary and herbal sources Luteolin is widely distributed in edible plants, culinary herbs, and beverages, contributing substantially to dietary flavonoid intake

This regulation was shown to occur under the direct transcriptional control of GA-binding protein alpha (GABPA)a critical Ets-family transcription factor that acts as a master regulator of mitochondrial biogenesis by controlling the expression of nuclear-encoded mitochondrial proteins, and whose direct binding to the PHB2 promoter makes it a key upstream determinant of the cells capacity for mitophagy (60)