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She began wasting away, with her muscles deteriorating so much that she needed a walker and her front teeth crumbling from exposure to stomach acid

In addition, around 8% of individuals with a deletion have a unique or atypical deletion size (i.e., not type I or II) due to various causes, such as unbalanced translocations ( Figure 1 Maternal uniparental disomy (mUPD), where both copies of chromosome 15 come from the mother, is responsible for approximately 35% of PWS cases and results from errors during meiosis

Scheimann AO, Butler MG, Gourash L, Cuffari C, Klish W

Smaller meals, lean proteins, adequate hydration, and reduced fat intake make the starting dose period significantly more comfortable

GAF is the McNeil Professor of Translational Medicine and Therapeutics