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Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

The primary active constituents in Lonicera japonica include chlorogenic acid, luteolin, and volatile oils, which collectively confer properties such as heat-clearing and detoxification, antibacterial and antiviral action, anti-inflammatory and swelling-reducing effects, as well as potent antioxidant capabilities

Current clinical management primarily relies on palliative approaches including oral nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy, while effective disease-modifying drugs remain unavailable [3, 4]

Doi: 10.1001/jama.2013.278040