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Proc Natl Acad Sci USA.1984;81:9359

Notably, direct gene editing via CRISPR-Cas9 introduces permanent double-strand breaks, which carry risks such as off-target mutations and unintended genomic rearrangements

[DOI] [PMC free article] [PubMed] [Google Scholar] 76.Bastola M.M., Locatis C., Maisiak R., Fontelo P

However, NAC is easily absorbed after oral administration, and can be used as a building block for glutathione synthesis