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SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase

While weight loss amplifies these benefits, the medication's metabolic effects on insulin signaling occur independently, making it a treatment for PCOS pathophysiology rather than just a weight-loss tool

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Department of Health and Human Services recommend at least 150 minutes of moderate-intensity aerobic activity weekly, along with resistance training 2-3 times weekly

After clinician review, both treatments continued without adjustment, and symptoms were monitored to ensure comfort and safety