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doi: 10.1089/ars.2020.8134, 102 RavenE

B.YugarL

The approach is scientifically interesting but operates through a long, indirect chain strain colonization gut lining improvement L-cell activity GLP-1 production

One such example involves utilizing a smaller Cas9 ortholog from Staphylococcus aureus (SaCas) (3.15 kb), which is ~1 kb shorter than the SpCas9, so that the CRISPR-Cas9 construct and gRNA can fit within a single AAV vector [159, 160]