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Proteomics and metabolomics analyses were supported in part by Core Scholarships from the Vanderbilt University Medical Center Digestive Disease Research Center, funded by NIH grant P30DK058404, the Vanderbilt Ingram Cancer Center support grant P30CA068485, and NIH grant S10OD023514 (to KLS)

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The main localization is pretibial and is associated with acropachy (digital clubbing, swelling of digits and toes, and periosteal reaction of extremity bones) in 20% of patients