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The gastrointestinal side effect profile was consistent with the GLP-1 agonist class: Nausea (most common, generally transient) Vomiting Diarrhea Decreased appetite Constipation These adverse events were described as generally mild and infrequently led to treatment discontinuation

This complex interacts with RNA polymerase II (RNAP II) and stimulates the initiation and elongation of transcription

persistent vomiting preventing fluid intake

One A 2021 review of research suggests that a combination of protein and calcium may help trigger increased GLP-1 secretion

This clear functional distinction is central to the KLOW vs KPV debate