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Making the Transition: A Step-by-Step Guide If you are currently on metformin and interested in starting a GLP-1 medication, following a structured process can help ensure your safety and success

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4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

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The concurrent increase in expenditure from glucagon receptor activation may partially offset this adaptation, allowing weight loss to continue for longer before plateauing

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