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2a,eh), GLP-1/tesaglitazar (50 nmol kg 1 per day), but not equimolar treatment with the GLP-1RA or tesaglitazar alone, decreased body weight in obese and diabetic db/db mice (Fig

We observed that GLP-1MK-801 has similar receptor signalling properties at the GLP-1 receptor compared to the parent GLP-1 analogue as well as to the pharmacokinetically optimized GLP-1 receptor agonists semaglutide and liraglutide (Extended Data Fig

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However, due to the lower yield only one repeat was carried out and an average EC 50 was not determined