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A retrospective analysis suggested that these complications were primarily observed among participants with proliferative or preproliferative retinopathy at baseline who experienced substantial reductions in HbA1c

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The combination of suppressed T3 and T4 levels with elevated TSH indicates a specific endocrine disruption that, when paired with the evidence of cellular injurynamely, the tissue upregulation of pro-apoptotic markers (Caspase-3 and Bax) and oxidative stress indicators like MDAforms a highly suggestive profile of GLP-induced cellular demise

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