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Altered gut microbiota may increase intestinal permeability, allowing metabolites like LPS into circulation, triggering chronic inflammation and insulin resistancekey features of PCOS (80)

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14 , 66 , 67 Microbiota exert their effects through direct cross-talk with tissues other than the intestine

MTs can prevent both diabetes- and angiotensin (AngII)-induced cardiac ER stress and associated cell death, likely due to their antioxidant properties, which may be responsible for MT-induced prevention of DCM [150]

Furthermore, Ca 2+ channels in various organelles, such as the lysosome or endoplasmic reticulum, have effects on autophagy (Decuypere et al., 2011a