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(2023), which included 18 randomized controlled trials, revealed that supplementation of probiotics, prebiotics, and synbiotics in CKD patients could significantly lower C-reactive protein, IL-6, and IS and improved levels of high-density lipoprotein cholesterol in comparison to the control group, but had no substantial effect on p-CS, low-density lipoprotein, cholesterol, TNF-, triglyceride, albumin, hemoglobin, total cholesterol, phosphorus, calcium, or uric acid in the serum of the patients (Chen C

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