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Most studies have focused on HO-1 affecting diabetic complications through its antioxidant, anti-apoptotic, and anti-inflammatory effects, but HO-1 has also shown a role in programmed cell death that cannot be ignored
In contrast, the expression of low-density lipoprotein receptor (LDLR), a main cholesterol transporter, remained unchanged, suggesting that cholesterol uptake from extracellular sources may compensate for reduced cholesterol biosynthesis (S8A Fig)
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